Our VHH Antibody Platform
At Cortalix, every VHH antibody program is built on a single foundation: our proprietary FC8TM scaffold framework, humanized, thermally stable, aggregation-free, and designed for clinical translation from the outset.
From that foundation, we’ve built a suite of platforms spanning discovery, multispecific engineering, half-life extension, and CAR-T design, each modular, and each ready to plug into the next.
Discovery Platform
VHH discovery via FC8TM: ribosomal display, screening a functional diversity of up to 1014 variants, transitioning seamlessly into phage display for precise hit enrichment. For the most complex or conformational targets, we complement this with immune library discovery.
- Up to 1014 functional diversity via ribosomal display
- Animal-free, fast, clinical-ready by design
- Immune libraries available for complex or conformational targets
Our platform for multivalent and multispecific VHH antibody constructs. By linking two, three, or more VHH domains with carefully selected linkers, we create bispecific, multi-epitope, or valency-tuned constructs, without sacrificing the stability and solubility of monovalent VHHs.
- Bi- and tri-specific constructs
- Superior stability compared to scFv or Fab fragments
- Applications in oncology, targeted therapeutics, radiopharmaceuticals, and inflammation
AlbuFlexTM Platform
Our albumin-binding VHH antibody platform, designed to exploit the natural half-life extension and biodistribution properties of serum albumin, giving you tunable control over the pharmacokinetics of your VHH therapeutic.
- Tunable half-life extension through modular albumin-binding design
- Integrates directly into the MultiDomeTM platform
- Applications in oncology, targeted therapeutics, radiopharmaceuticals, and inflammatory disease
CARVexTM Platform
- Optimized tonic signaling (PCP-tuned) to reduce T-cell exhaustion
- Monospecific, bispecific, or tandem NanoCAR designs
- Superior biophysical properties compared to scFv-based CARs
Let’s Discuss Your Project
Not sure which platform fits your target or application? We’re happy to map out the best route together.