VHH Antibody discovery
SMART
VHH ANTIBODY
DISCOVERY
1014 functional possibilities. Zero compromise
Ribosomal display diversity combined with phage display precision
in one integrated VHH discovery platform
Smart VHH Antibody Discovery
Cortalix offers cutting-edge VHH antibody discovery & development services built on a proprietary synthetic scaffold framework engineered from the ground up for clinical translation.
Our synthetic VHH libraries are powered by a sequential ribosomal display and phage display pipeline: starting with a functional diversity of up to 1014, transitioning seamlessly into precise phage display enrichment. The result is a clinical-ready lead candidate, not a starting point for re-engineering.:
Whether you’re developing an oncology therapeutic, a radiopharmaceutical tracer, or a CAR-T construct, every VHH we deliver starts from the same clinical-ready foundation.
What We Offer
VHH Discovery via Proprietary Synthetic Libraries
Ribosomal display (1014 functional diversity) transitioning seamlessly into phage display, all within our proprietary clinical-ready scaffold framework. Animal-free, fast, and built for therapeutic development.
Lead Optimization
CDR grafting, humanization, stability profiling, affinity maturation
Engineering & Conjugation
Custom design: Fc-fusion, chelation, fluorophores, nanobody-drug-conjugates, linkers, toxins, multispecifics
Preclinical Readiness
Expression, purification, in vitro profiling, Radiopharmaceutical and CAR-T optimization, GMP transfer support
Why Choose Cortalix
Clinical-Ready Scaffold by Design: Our proprietary synthetic VHH framework is >90% humanized, thermally and pH-stable, aggregation-free, and free of liability sites, by design, not by post-discovery engineering. Every lead we deliver is ready for the next step in your program.
…and fully animal-free; no immunization required.
Unmatched Discovery Diversity: Our ribosomal display platform starts every campaign in a pool of 1014 functional VHH variants, all screened within our proprietary clinical-ready scaffold framework. Maximum coverage, zero diversity sacrifice.
Deep Binding Potential: Immune libraries offer strong, specific VHHs
Full Engineering Support: From discovery to preclinical applications
Experienced Team: Decades of combined VHH antibody development expertise
Contact Us
Ready to eliminate your lead optimization bottleneck? Contact us for a free scientific intake session, tell us your target, and we’ll map the fastest route to a clinical-ready VHH candidate.
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