VHH Antibody discovery
SMART VHH ANTIBODY DISCOVERY
Built on FC8TM
up to 1014 functional VHH variants,
one clinical-ready lead
Smart VHH Antibody Discovery
FC8TM libraries are powered by a sequential ribosomal display and phage display pipeline: starting with a functional diversity of up to 1014, transitioning seamlessly into precise phage display enrichment. The result is a clinical-ready lead candidate, not a starting point for re-engineering.
Whether you’re developing an oncology therapeutic, a radiopharmaceutical tracer
What We Offer
Ribosomal display (up to 1014 functional diversity) transitioning seamlessly into phage display, all within our proprietary clinical-ready FC8TM scaffold. Animal-free, fast, and built for therapeutic development.
Lead Optimization
CDR grafting, humanization, stability profiling, affinity maturation.
Engineering & Conjugation
Custom design: Fc-fusion, chelation, fluorophores, nanobody-drug-conjugates, linkers, toxins, multispecifics.
Preclinical Readiness
Expression, purification, in vitro profiling, radiopharmaceutical and CAR-T optimization, GMP transfer support.
Why Choose Cortalix
Our proprietary FC8TM framework is >90% humanized, thermally and pH-stable, aggregation-free, and free of liability sites, by design, not by post-discovery engineering. Every lead we deliver is ready for the next step in your program, and fully animal-free: no immunization required.
Unmatched Discovery Diversity
Our ribosomal display platform starts every campaign in a pool of up to 1014 functional VHH variants, all screened within the FC8TM scaffold. Maximum coverage, zero diversity sacrifice.
Deep Binding Potential
For targets that call for natural affinity maturation, our immune libraries deliver strong, highly specific VHHs, with CDRs that can be grafted straight onto the FC8TM framework for a stable, humanized backbone.
Full Engineering Support
From initial discovery through CDR grafting, humanization, conjugation, and multimerization, to expression and GMP transfer support, we support your VHH candidate at every stage on its way to a preclinical and clinical application.
Experienced Team
Our team brings decades of combined experience in VHH antibody discovery, engineering, and translational biotech, backed by a track record of taking candidates from target to clinical-ready lead.
Contact Us
Ready to eliminate your lead optimization bottleneck? Contact us for a free scientific intake session, tell us your target, and we’ll map the fastest route to a clinical-ready VHH candidate.
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